Conditions  »  Kidney Failure

 The best treatment for Kidney failure, disease, and infection

Kidneys are the organs that filter the toxins from your body. The dysfunction of kidneys is commonly termed as kidney failure. It is a condition in which a patient’s kidneys lose the ability to remove waste from the body.

Function of Kidneys

The kidneys are bean-shaped organs on the sides of your spine just below your ribs. Each kidney is about 10to 11 cm long in adults. Kidneys are unique organs with a significant role in the human body. Some crucial functions your kidneys perform include:

  • They filter your blood and excrete toxins from your body. Kidneys send toxins to your bladder, which are later eliminated by urination
  • They are involved in fluid /electrolytes and acid-base maintenance
  • They have several hormonal functions like preventing anemia and vitamin D deficiency.
  • Kidneys are also involved in your blood pressure maintenance

 Kidney infections are a common condition, whereas kidney failure patients are increasing every day. The demand for kidney transplants is increasing. High blood pressure and type II diabetes are on the rise that is contributing to kidney related ailments. But unfortunately, there are not enough donor kidneys available to meet the growing requirements. Stem cell-based therapies offer a long-term solution for the patients of kidney failure.

What is a Kidney infection?

Kidney infection is a kind of urinary tract infection (UTI) that generally begins in your urethra or bladder and travels to one or both of your kidneys. A kidney infection requires prompt medical attention. If not treated properly, a kidney infection can permanently damage your kidneys, or the bacteria can spread to your bloodstream and cause a life-threatening disease. Most kidney infections start as bladder infections. Bladder infections usually get better with antibiotics; however, if a patient develops kidney infections, again and again, there is a probability of developing kidney diseases like scaring of kidney leading to kidney failure in some cases.

Are you aware of Kidney failure?

This kidney disease is the gradual loss of the ability of your kidneys function. The process is slow and can be cured if detected early. Factors that lead to kidney’s dysfunction are

  • toxic exposure to environmental pollutants
  • kidney trauma
  • certain acute and chronic diseases
  • severe dehydration

When your kidneys are overloaded with toxins and excess fluids, they can’t perform their regular function and develop kidney infections that can result in kidney failure.

Symptoms of Kidney Failure

As kidney function decreases, the symptoms are related to the inability to regulate water and electrolyte balances, excrete waste products from the body, and promote red blood cell production. Kidney failure has different manifestations. The early kidney disease depicts symptoms like:

  • Swelling –on the face, legs, ankles or feet due to fluid retention
  • Decreased urine output
  • Backache just above your waist
  • Shortness of breath

Kidney dysfunction is a gradual detrition of kidney health. In the early stages of kidney diseases you may have little to no symptoms. Chronic kidney diseasewould not be  apparent until your kidney function is damaged to a good extent. Signs of chronic kidney disease develop slowly. Symptoms of kidney failure that are displayed in later stages include:

  • Nausea
  • Vomiting
  • Loss of appetite
  • Fatigue and weakness
  • Sleep issues
  • Changes in urine quantity
  • Swelling of feet and ankles
  • Itching and irritability
  • Chest pain because of fluid buildup around heart lignings.
  • Shortness of breath
  • High blood pressure (hypertension) 
  • Blood and frothiness in urine

If the symptoms are untreated, they may lead to a life-threatening situation.

How to asses kidney failure?

Kidney disease and infections are initially asymptomatic in some patients; they show up later in the stages of the disease. You can perform a simple blood test, including creatinine and glomerular filtration rate (GFR) or urine test, to diagnose the prevalence of the disease. Also, imaging studies like ultrasound can help detect kidney infections.

Causes of kidney failure

Kidney failure may occur from an acute situation that injures the kidneys or from chronic diseases that gradually cause the kidneys to stop functioning.

Acute Kidney failure occurs rapidly and may get recovered when the underlying problem is resolved. Acute kidney failure is also called acute renal failure or acute kidney injury — develops quickly.

  • Causes of Acute Kidney failure

 Acute kidney failure is most common in:

  • People who are already hospitalized, particularly in critically ill people who need intensive care.
  • Acute kidney failure may occur if you have impaired blood flow to the kidneys.
  • If you experience direct damage to your kidneys or your kidneys’ urine drainage tubes (ureters), become blocked, and wastes can’t leave your body through your urine

Chronic kidney failure occurs slowly and affects one or both kidneys over the years. CKD is a progressive disease, and usually, nephrologists are concerned about slowing the progression of the disease. Chronic kidney disease or chronic renal disease, is quite common and goes undetected and undiagnosed until the disease is well advanced.

Chronic kidney disease affected 753 million people globally in 2016: 417 million females and 336 million males. In 2015 it caused 1.2 million deaths. Common symptoms include, high blood pressure, fatigue blood in urine.

  • Cause of Chronic Kidney Failure

Common causes of chronic kidney failure are related to any disease like:

  • Diabetes and specific kidney diseases, which includes polycystic kidney disease
  • High Blood pressure
  • kidney stones
  • an enlarged prostate
  • blood clots within your urinary tract
  • damage to your nerves that control your bladder
  • drugs and alcohol

Stages of kidney failure

Kidney failure is classified into five stages. The patient’s complications and symptoms increase as the stages progress.

Stage 1In this stage, the symptoms are very mild. You may experience no symptoms but some damage is present. You may detect the progressive kidney disease through some blood or urine tests.

Stage 2kidney diseases are still considered a mild form, but detectable issues like protein in the urine or physical damage to the kidneys may be more visible.

Stage 3 of Kidney disease is considered moderate. Your kidneys aren’t working correctly. The symptoms are more apparent, like swelling in hands and feet, back pain, and changes to urination frequently.

Stage 4 kidney disease is now considered moderate to severe. The kidneys are not functioning properly, but are not in complete kidney failure yet. Symptoms of stage 4 include complications like anemia, high blood pressure, and bone disease. Your doctors will intent you to go on treatments designed to slow down the damage.

In Stage 5 your kidneys are near to complete failure. Signs of the loss of kidney function will start showing up. These include vomiting and nausea, chest pains and trouble breathing. At this stage, you will need regular dialysis or a kidney transplant.

Treatment of Kidney Diseases

There are several treatment options available for kidney failure. In the case of acute kidney failure resolving the underlying issue with some medication may help restore kidney functions. If one of the damaged or diseased kidneys is removed, the other can perform the function efficiently in the body. However, in the case of chronic kidney failure, the patient may require assistance for the extent of damage done to the kidneys. Treatment options available include:

a)   Dialysis

Dialysis is a process of filtering the blood from wastes using machines. In short, the machine performs the function of your kidneys. Dialysis does not cure the disease but helps the patient to extend his life if taken regularly scheduled treatments.

b)   Kidney transplant 

Kidney transplant is another treatment option for kidney failure disease and can help the patient to be no longer dependent on dialysis. The process is expensive, with long waits for the compatible donor. For some aged patients or those with other health conditions the kidney transplant surgery might not be the right treatment option.

c)    Stem Cell Treatment 

Biomedical research is treating many health issues around the world, which had no proper treatment in the past. Scientists have successfully grown kidney organoids from adult patients’ pluripotent stem cells. These mini-kidneys have similar cell structures to kidneys, therefore allowing researchers to use them to treat kidney failure diseases.

Several different types of cells from the bone marrow have been tested in clinical studies for potential use in kidney disease. Among all the cells under investigation, a type of cell commonly named mesenchymal stem cells (MSCs) have shown the most promising results to date. Nephrons are kidney cells that can be developed from Mesenchymal stem cells (MSCs). Researchers are investigating the therapeutic effects of these bone marrow-derived MSCs in the kidney disease setting. They have suggested these cells may release proteins that can help kidney cells to grow, inhibit cell death, and could encourage the kidney’s stem cells to repair kidney damage.

How to get stem cell treatment in Pakistan?

Shifa Rejuvenation Clinic is now providing the regeneration treatment of kidney failure disease in Pakistan. The treatment has the potential to treat chronic kidney failure from adult stem cells, creating hope for the patients of this chronic ailment. The patients who are treated for kidney failures at Shifa have shown improvements in 6 to 8 weeks.

For consultations, get in touch by contacting us at (051) 835-7790 or email at [email protected]

      Best medical decision I ever made! The stem cell procedure is quick, easy and has no recovery down time! Great alternative to surgery if that is an option.



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