Stem cell therapy is an important treatment modality for a variety of diseases. The potential of stem cells to differentiate into all cell types in the body and to self-renew makes them a promising tool for regenerative medicine. In HIV AIDS infection, stem cell therapy may hold particular promise.
Human Immunodeficiency Virus
HIV AIDS infection leads to a state of chronic immune activation and inflammation. This results in rapid depletion of CD4+ T cells, expansion of the HIV reservoir, and development of a variety of pathological complications including cardiovascular disease, liver disease, neurocognitive disorders, osteoporosis, cancer, etc. Although combination antiretroviral therapy can suppress viral replication and preserve CD4+ T-cell counts, it cannot reverse or treat HIV AIDS infection.
One potential strategy to improve the clinical outcome of HIV AIDS infected patients is to use stem cell-based approaches to promote endogenous regeneration of damaged cells and tissues. Stem Cell Therapy for HIV (Aids) has been shown to differentiate into functional CD4+ T cells and even entire functional immune systems, which may help to rebuild a damaged immune system.
In recent years, many groups have been working on using stem cell transplantation in the treatment of HIV AIDS infection. This review intends to summarize the latest studies on the role of stem cell therapy for HIV AIDS patients.
HIV infection results in significant damage to the immune system. The virus directly infects CD4+ T cells, macrophages, and dendritic cells, resulting in the depletion of these critical cell populations. HIV AIDS causes direct damage to the bone marrow where all blood lineages are generated. In addition, HIV AIDS infection is associated with elevated levels of pro-inflammatory cytokines such as TNF-alpha and interferon-gamma.
All of these factors together contribute to the development of HIV-related bone marrow failure, or acquired immunodeficiency syndrome (AIDS) associated lymphoma. This results in a significant decrease in the number of functioning immune cells, leading to increased susceptibility to infection and cancer.
Stem Cell Therapy a Potential Treatment
Stem cell therapy has been shown to be beneficial in a number of diseases associated with immune deficiency, including HIV AIDS infection. Umbilical cord stem cells are the current gold standard for Stem Cell Therapy for HIV (Aids). It involves the replacement of the entire bone marrow with donor cells, which can repopulate the immune system and restore normal immune functions. This approach has been shown to be successful in preclinical studies and clinical trials. The ability of umbilical cord blood stem cells to differentiate into several lineages creates the possibility of treating diseases such as sickle cell anemia, thalassemia, and lymphoma, which are commonly seen in HIV AIDS infected patients.
In a study published in the journal Blood in 2007, transplanted umbilical cord blood stem cells into HIV AIDS infected patients. The results showed that Stem Cell Therapy for HIV (Aids) was able to improve the number of CD4+ T cells and decrease the viral load. A study published in the journal Stem Cells in 2011, showed that umbilical cord blood stem cell transplantation was able to partially restore the function of the immune system in HIV AIDS infected patients.
So, if you are having HIV AIDS symptoms or diagnosed with HIV AIDS infection then you should consult with an experienced stem cell practitioner like Shifa Rejuvenation Clinic. They can guide you as per your condition.