Stem Cell Therapy for Ovarian Failure

Ovarian failure, also termed ovarian insufficiency or ovarian dysfunction, is the loss of function of the ovaries. Thus ovarian failure means that your body will not be able to produce eggs and estrogens (the female hormones).

Typically there are two major types:

• Primary ovarian failure
• Secondary ovarian failure  

One of the ovarian failure types is ovarian hypofunction or primary ovarian insufficiency. It may be caused by a genetic mutation that affects ovarian development, for example, Turner’s syndrome. In this case, there might be structural abnormalities, chromosome problems, and infertility from puberty.

Primary ovarian failure is defined as the cessation of ovarian follicular activity, while secondary ovarian failure involves ovarian dysfunction that results from other pathologic conditions. The type of ovary failure may be menopause, premature ovarian insufficiency (POI), or the triad of POI with short menstrual cycles and elevated FSH levels in association with a 46, XX karyotype. HHV-8 has been associated with ovarian failure in posttransplant lymphoproliferative disease (PTLD) and primary ovarian insufficiency (POI) with short menstrual cycles and elevated follicle-stimulating hormone (FSH) levels in association with a 46, XX karyotype. HHV-8 has been associated with ovarian failure in posttransplant lymphoproliferative disease (PTLD) and POI.

Ovarian dysgenesis, which is an early form of ovarian failure during embryonic development, is often caused by external factors that affect ovarian development. This form can be divided into three subtypes, known as Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH), ovarian hypoplasia, and 46, XX ovarian dysgenesis. The latter is also called Swyer syndrome.

Ovarian hypofunction may also be caused by ovarian infections, ovarian torsion, ovarian trauma, ovarian cysts, and cancer treatment with chemotherapy or radiation.

The woman’s menstruation cycle stops at puberty, but some women experience normal menstrual periods until they are 35 years old. The infertility rate of ovarian failure types is almost 100%, but some women have children through in vitro fertilization.

Ovarian failure types may cause a condition called ovarian insufficiency syndrome, where ovarian function is reduced but not stopped completely. Here there might be a relative over-production of luteinizing hormone by the pituitary gland. Ovarian dysfunction causes anovulation and menstrual disturbances.

Primary ovarian failure types can lead to a rapid ovarian failure syndrome. This ovarian failure syndrome manifests itself as a sudden loss of ovarian function, also known as ovarian crisis. It may happen after strenuous physical activity or a serious illness that causes high fever.

Secondary ovarian failure, which is the other major type of ovarian failure, occurs when ovarian function ceases due to natural ovarian aging (menopause) or as the result of surgical removal of the ovaries, for example after a hysterectomy.

A diagnosis of ovarian failure should be made by a physician. Women with this disease appear to have the same clinical profile as women who are close to menopause, i.e., an absence of menstrual periods for 6 months in the absence of other diseases. The incidence of ovarian failure is 0.2%–0.5% in women with ovarian failure who are less than 50 years of age. History and physical examination, pelvic ultrasonography, ovarian volume assessment, ovarian biopsy, ovarian function tests (elevated FSH), cytogenetic testing, and HHV-8 testing are used to establish a diagnosis.

Clinical features of ovarian failure include primary amenorrhea, secondary amenorrhea, the absent ovarian size on pelvic ultrasonography, elevated FSH levels in women older than age 40 years, ovarian volume less than 1.5 cm 3, ovarian biopsy showing absence of ovarian follicles, and elevated anti-Müllerian hormone (AMH) levels in perimenopausal women. Ovarian failure may be manifested as a short menstrual cycle (i.e., less than 26 days), ovarian dysfunction after chemotherapy or pelvic irradiation, ovarian cysts, ovarian epithelial hyperplasia on ovarian biopsy, ovarian hyperandrogenism (e.g., hirsutism), elevated FSH levels in young women, ovarian volume less than 1.5 cm3 or ovarian biopsy showing absence of ovarian follicles.

Testing for an ovarian function includes the use of pelvic ultrasonography to measure the ovarian size and serum FSH levels. Women who are perimenopausal have increased ovarian volume, whereas menopausal women have decreased ovarian volume. Women with ovarian failure have no ovarian follicles on ovarian biopsy or ovarian tissue. The presence of ovarian cysts does not rule out ovarian failure because these cysts may be seen in the early stages of a polycystic ovarian syndrome (PCO) and in ovarian failure.

Pelvic ultrasonography is used to measure ovarian volume and ovarian biopsy shows the absence of ovarian follicles or ovarian tissue. In addition, the presence of ovarian cysts does not rule out ovarian failure because these cysts may be seen in the early stages of polycystic ovarian syndrome and ovarian failure.

Stem Cells are very effective for the treatment of Ovarian Failure. The umbilical cord stem cells are FDA-regulated stem cells that are used for the treatment of ovarian failure. If you are having ovarian failure or any type of complication with ovarian failure, consult with a well-reputed stem cell hospital for treatment. Contact Shifa Rejuvenation Clinic today and find out how we can help you live a healthier life. Call us now on (051) 889-6711 for the treatment.